Recently, the Journal of Biological Chemistry published the research paper of Structure and function of allophanate hydrolase by Xiang Song Research Group, Institute of Nutritional Sciences, Chinese Academy of Sciences and Shanghai Institutes for Biological Sciences. This study parsed the three-dimensional structure of allophanate hydrolase (AH) and revealed the mechanism of its catalytic reaction.

AH is distributed in various microorganisms and catalyzes the conversion of allophanate to ammonia. AH and urea carboxylase (UC) form a urea amidolyase (UA) complex, which catalyzes the conversion of urea to ammonia. It is an important link for many microorganisms to use urea as a nitrogen source for their metabolism. Urea is a metabolite of various nitrogen-containing biomolecules. Using it as a nitrogen source is an important part of the cycle of nitrogen in the life cycle. However, the three-dimensional structure of AH and its specific role in urea (allophanate) catalysis to ammonia The mechanism is unclear.

On the basis of revealing the structure of UC and the catalytic reaction mechanism in the early stage, Fan Chen, a doctoral student under the guidance of Prof. Song Song, conducted a cooperative research with Yin Huiyong Group of the Institute of Nutrition and analyzed the crystal structure of AH using crystallography. The results show that: AH is composed of two catalytic domains, respectively participating in one step of the two-step catalytic reaction, and reveals the catalytic mechanism of each step. Interestingly, the study found that one step reaction may represent a novel decarboxylation reaction. This work not only promoted people's understanding of the functional mechanism of UA and microbial absorption of urea as a nitrogen source, but also expanded the understanding of biological decarboxylation reactions.

This work was funded by the Ministry of Science and Technology and the Chinese Academy of Sciences.

Name

OSB, oriented strand board

Size

1220*2440mm(4'*8') 1250*2500mm

Material

poplar, fruit tree, pine or mixed

Density

680-700KG/CBM

Thickness

9/12/15/18mm

Thicknee tolerance

+/- 0.3mm

Grade 

OSB2, OSB3

Glue

MR, melamine,WBP

MOQ

1*20GP container

Delivery time

Usually within 20 days, if urgent 15 days would be ok.

Packing

Pallet packing

21CBM/8pallets/20GP 

41CBM/16pallets/40HQ

Loose packing

25.8CBM/20GP do not recommend 

loose packing in 40HQ

Supply ability

5000cbm/month

Payment terms

T/T or L/C at sight

Usage

Furniture making, desk making, sidewall, cabinet making,

 Decoration, subfloor, roof, prefab house and so on.

OSB

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