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Shanghai Xinzhuang Instrument Co., Ltd. is a leading domestic manufacturer of scientific instruments, known for its LNB brand centrifuge, which is energy-efficient and environmentally friendly. With professional manufacturing processes, the company ensures high-quality products at competitive prices. The attention to detail in material selection and craftsmanship makes their equipment reliable and durable. Since its establishment, the company has continuously focused on product innovation, upgrades, and introducing advanced, user-friendly, and stable instruments. To better support customers, they also employ experienced application engineers who are available to answer questions anytime.
Leveraging its core R&D capabilities, Shanghai Xinzhuang has developed a wide range of scientific instruments, including low-temperature constant temperature devices, ultrasonic instruments, box-type instruments, microbial instruments, ice-making refrigerators, and laboratory accessories. This has helped them build a solid foundation for various scientific product technologies and development patterns.
One of their key products is the LNB solid phase extraction (SPE) device. SPE technology, which emerged in the late 1970s, has evolved significantly, with the development of SPE columns featuring different stationary phases. Over time, SPE has become an essential technique for sample pretreatment, adapting to the needs of various samples and improving the separation of different compounds.
Solid Phase Extraction involves using a solid adsorbent to selectively retain target compounds from a liquid sample, separating them from the matrix and interfering substances, and then eluting or desorbing them to achieve purification and concentration. As a widely used sample preparation method in laboratories, SPE plays a crucial role in analytical workflows.
Although SPE shares similarities with High Performance Liquid Chromatography (HPLC) in terms of separation mechanisms and stationary phase selection, there are key differences. SPE columns typically use larger particle sizes (>40 µm), compared to HPLC columns (3–10 µm). This leads to lower efficiency, with SPE columns producing only 10–50 theoretical plates, while HPLC columns can reach over 10,000. Therefore, SPE is not ideal for separating compounds with very similar properties. Instead, it often uses a digital switching mode, where the analyte is either not retained or fully eluted through a step gradient. Additionally, SPE columns are usually disposable, making them cost-effective for routine applications.
The main purposes of SPE include:
(1) Removing interferences that may affect subsequent analysis
(2) Enriching trace components to enhance detection sensitivity
(3) Changing the solvent to match the analytical method
(4) Performing in situ derivatization
(5) Removing salts from the sample
(6) Simplifying sample storage and transportation
Among these, purification and enrichment are the most critical aspects of SPE. Shanghai Xinzhuang Instrument Co., Ltd. continues to innovate and provide reliable solutions for researchers and laboratories around the world. For more information, feel free to contact us at [http://](http://).