Nanomaterials have various excellent physical and chemical properties. Assembling nanomaterials into ordered superstructures is a key step in studying the interaction between nanomaterials and constructing new nanodevices. Template guidance is the most widely used "bottom-up" strategy. Compared with templates obtained by chemical synthesis and physical processing, biomaterial templates are of uniform size, easy to modify and easy to prepare in large quantities, and have unique advantages in guiding the assembly of nanostructures.

Recently, the research team of Wang Qiangbin, a researcher at the Institute of Nanotechnology and Nanobionics, Chinese Academy of Sciences, worked in the early stage on the controllable preparation of three-dimensional discrete nanostructures guided by Virus based nanoparticles (VNPs) (Angew. Chem. Int. Ed. , 2011, 50: 4202) and the single functionalization strategy of protein nanoshells (J. Am. Chem. Soc., 2011, 133: 20040), developed a more convenient and adjustable three-dimensional discrete hybrid core Assemble the nanostructure assembly method (Figure 1).

The researchers first confirmed the high compatibility of SV40 VNPs packaging nanoparticles, so that different nanoparticles can be packaged inside it, including CdSe @ ZnS, Ag2S quantum dots (QDs) and gold nanoparticles (AuNPs); The interaction between natural lysine and arginine side chain amino groups and AuNPs (electrostatic attraction and gold-amine direct connection), assembles AuNPs on the surface of VNPs, forming a high-density (~ 27 AuNP / cluster) three-dimensional AuNPs cluster (Figure 2), and the density of AuNPs can be adjusted by changing the electrostatic interaction between VNPs and AuNPs.

The ordered discrete structures formed by these different nanoparticles are difficult to achieve with a "top-down" strategy and have important application value in disease diagnosis and treatment, energy harvesting, biosensing, and catalysis. This work also provides a universal and easy way for protein nanostructures to guide the assembly of nanomaterials.

Related results were published in Small (10.1002 / smll.201201047).

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