Glucose-6-phosphate dehydrogenase

Glucose-6-phosphate dehydrogenase (Glucose-6-phosphate dehydrogenase, G-6-PDH, EC1.1.1.49) was earlier in the study of humans and is widely present in most of the human body Among the tissues, the activity of red blood cells and white blood cells is the highest, and the enzyme activity in serum is 20% of the red blood cells. The polymorphism of horse blood red blood cells G-6-PDH was first discovered by Sandberg et al. Enzyme-catalyzed analysis of NADP, glucose-6-phosphate, glucose-1-phosphate, hexose hormone, and phosphate glucose isomerase (PGI). In the presence of sugar hormones, the analysis of glucose is highly efficient and specific. From a clinical point of view, the measurement of glucose-6-phosphate dehydrogenase has diagnostic value for the study of drug-induced hemolytic anemia. The causes of changes in glucose-6-phosphate dehydrogenase levels in erythrocytes of susceptible people are as follows: ① drug induction; ② non-drug induction; ③ broad bean disease induction; ④ disease induction. For people who are frequently exposed to hemolysis reagents, it is more likely to cause glucose-6-phosphate dehydrogenase deficiency, even after blood transfusion red blood cells will produce hemolysis. Therefore, blood donors with this possibility should be prohibited. It is well known that glucose-6-phosphate dehydrogenase is one of the adjustment factors for maintaining the activity of red blood cells. If you avoid ingestion of substances that are toxic to red blood cells, you can prevent hemolysis due to glucose-6-phosphate dehydrogenase deficiency to a certain extent. Glucose-6-phosphate dehydrogenase has high selectivity to glucose-6-phosphate, requiring a specific activity of at least 140U / mg protein. Glucose-6-phosphate dehydrogenase extracted from yeast can use NADP + as a substrate. Mg2 + at a concentration of 5-10 mmol / L can promote enzyme production; however, higher concentrations of Mg2 + or other divalent ions can inhibit the activity of the enzyme. Nucleoside monophosphate and certain di- and triphosphates, such as ADP, ATP, guanosine triphosphate (GTP), uridine triphosphate (UTP) play an inhibitory role. Glucose-6-phosphate dehydrogenase crystallizes in ammonium sulfate solution with pH 6 and concentration of 3.2mol / L. It can be stored stably at 4 ℃ for 9 months, and freeze-dried samples can be stored at 4 ℃ month.

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